CAS 3381-88-2(Methasterone)

Description

Methasterone, also known as 17α-methyl-5α-dihydrotestosterone, is a synthetic anabolic androgenic steroid (AAS) developed in the 1950s. It is an orally active steroid and has been used by athletes and bodybuilders for its anabolic properties, including increased muscle mass and strength. Methasterone has also been studied for its potential medical applications, including treatment of osteoporosis and muscle wasting diseases.

Scientific Research Applications

1. Hepatotoxicity Studies

Methasterone, a nutritional supplement used for muscle mass build-up, has been found to cause severe hepatotoxicity. Shah et al. (2008) described cases where methasterone use led to jaundice and severe liver injury, highlighting the risks associated with its consumption. The study emphasizes the need for awareness of potential liver damage from methasterone usage (Shah et al., 2008).

2. Metabolism and Detection in Anti-Doping

Research by Zhang et al. (2016) identified potential biomarkers for methasterone misuse in human urine, using liquid chromatography and mass spectrometry. This study contributes to anti-doping efforts by identifying new metabolites of methasterone that can be detected for up to 10 days, aiding in the detection of its misuse in sports (Zhang et al., 2016).

Magalhães et al. (2019) also explored human metabolism of methasterone, focusing on the detection of new phase I urinary metabolites and their excretion kinetics. Their work provides insights into long-term metabolites of methasterone, which are crucial for doping analysis (Magalhães et al., 2019).

3. Microbial Transformation and Anti-inflammatory Activity

A study by Aamer et al. (2022) explored the microbial transformation of methasterone, leading to the creation of new metabolites. Interestingly, the study found that some of these metabolites displayed anti-inflammatory activity, suggesting potential therapeutic applications (Aamer et al., 2022).

Ahmad et al. (2017) conducted similar research, examining the biotransformation of methasterone. They found that some transformed products exhibited potent inhibition against TNF-α and NO, indicating potential for anti-inflammatory uses (Ahmad et al., 2017).

4. Methasterone Metabolism in Alternative Models

Geldof et al. (2016) used human liver microsomes and a chimeric mouse model to study the metabolism of dimethazine, which contains methasterone. This research aids in understanding the metabolism of designer steroids and their detection in anti-doping efforts (Geldof et al., 2016).

Similarly, Geldof et al. (2014) investigated the metabolism of methylstenbolone and its relation to methasterone using human liver microsomes and a chimeric mouse model. This study contributes to the knowledge of steroid metabolism and the detection of steroid misuse (Geldof et al., 2014).